8 Advantages of Adaptive Design in Clinical Trials

Explore our latest infographic to get a comprehensive overview of the advantages of adaptive design. 

1. Patient Focus
   Limiting patient exposure to drugs or doses that are not sufficiently effective.
   
   
2. Trial Efficiency
   Allowing trial completion with fewer patients, enriching the trial population in a subgroup of patients for whom the medication is effective.  
   
   
3. Early Termination
   Stopping the trial early if the medication is not effective.  
   
   
4. Optimal Selection
   Selecting a dose, a formulation or a treatment regimen for which the efficacy is good enough to be approved by health authorities.
   
   
5. Environmental Impact
   Reducing the environmental impact of clinical research.
   
   
6. Power Control
   In contrast, increasing the sample size to maintain or achieve the trial power could also prevent a study from failing for lack of power, and thus, have a better control of the Type 2 error.
   
   
7. Sample Size
   Adjusting, especially reducing, the required sample size needed may be crucial for a study conducted in a rare disease, or a disease that is more difficult to recruit due to comorbidities.
   
   
8. Dose Range
   Drug developers may study a wider range of doses.   

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Read the full article: Potvin D, D'Angelo P, Bennett S, Jankicevic J, Bissonnette R. Adaptive designs in dermatology clinical trials: Current status and future perspectives. J Eur Acad Dermatol Venereol. 2024 Apr 15. doi: 10.1111/jdv.20030. Epub ahead of print. PMID: 38619384. 

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