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Specialized CRO services for rheumatology studies.
We’re all in.
Rheumatology specializes in diagnosing and treating over 20 rheumatic and musculoskeletal diseases (RMDs) that can impact joints and organs in both children and adults. Given the complexity and variety of these conditions, a specialized CRO is essential. Indero serves your clinical trial needs from every side—from science to operations and protocols to patients–ensuring the highest standards of data integrity and reliability.
As your rheumatology CRO, Indero offers the expertise to advance a broad spectrum of indications. Our team understands the complexities and unique demands of immune-mediated diseases, bringing depth and precision to every study we support. Here are some of the indications we focus on:
SLE trials face unique complexities due to the disease’s heterogeneity, different treatment paradigms across the globe, uncontrolled use of background glucocorticoids, and use of convoluted composite endpoints that capture organ-specific responses and overall disease activity.
Systemic sclerosis is a rare autoimmune disease characterized by immune imbalance, fibrosis and vascular abnormalities, making endpoint selection and recruitment particularly challenging.
The spondyloarthritis spectrum encompasses a range of diseases sharing common inflammatory pathways but requiring distinct endpoints and trial designs.
Our team employs validated composite endpoints like SLE Responder Index (SRI), British Isles Lupus Assessment Group-based Composite Lupus Assessment (BICLA) and organ-specific indices such as EULAR/ERA-EDTA renal response and CLASI skin score.
We partner with specialized lupus centers to accelerate recruitment of well-characterized patients.
Centralized adjudication of disease activity at entry and during study duration by expert “lupus trialists” ensures consistent assessment of disease activity status across sites, enhancing data reliability, detection of efficacy signals and controlling placebo response rates.
We are familiar with the standardized imaging techniques (e.g., HRCT for lung fibrosis) and pulmonary function testing to capture subtle changes in disease progression.
Our trial network, focused on rheumatology sites, ensures access to experienced investigators and accelerates recruitment.
Rigorous training of site staff in mRSS (hands-on workshops with real patients and training certification) and lung function assessment ensures consistent, high-quality data collection.
We utilize centralized imaging reviews with radiologists trained in SpA standardized scoring systems (e.g., SPARCC, mSASSS).
Our dual expertise in dermatology and rheumatology ensures consistent staff training on assessment of both musculoskeletal and skin outcomes in PsA.
Clear protocol recommendations on how to manage emergent extra articular manifestations (e.g. uveitis, inflammatory bowel disease), clear derivation channels to relevant specialists for assessments and clear definitions of rescue therapy alternatives and IMP discontinuation rules.
Platform trial designs enable sponsors to evaluate multiple mechanism of actions, reducing costs and increasing trial efficiency.
Indero’s full-service model supports rheumatology studies from start to finish. With scientific and medical rigor, operational efficiency, and specialized clinical development, we prioritize data quality at every step. Our tailored insights and quality data ensure on-time, effective study execution.
Indero is a specialized CRO with deep expertise in rheumatology and dermatology, bringing over 25 years of experience in clinical trial delivery. Our full-service approach—from protocol design and patient recruitment to monitoring and biometrics—prioritizes data quality in all processes and training programs. This commitment equips biotech and pharmaceutical sponsors with the clinical rigor and medical expertise to drive rheumatology studies to success. Our operations span across the world, with capabilities in North America, Europe, Latin America, and Asia Pacific. Our dermatology connections include over 3,100+ investigators, making us a trusted partner for efficient, effective dermatology trials at a global scale.
“. . .From the initial synopsis development to the final stages of study conduct, the synergy between our teams was palpable and was underpinned by Indero’s strong relationships with sites, investigators and KOLs. . .”
Senior Vice President, Clinical Development
Indero successfully navigated the complexities of a study on Systemic Sclerosis (SSc), demonstrating strategies that enhanced subject retention and streamlined recruitment.
The Dermatology Center of Indiana and the Indiana Clinical Trials Center
“Outstanding level of support.
Indero has truly been a reliable CRO partner to us over the years and has continuously offered an outstanding level of support to our recruitment activities.”
A rheumatology CRO specializes and understands the caveats and challenges of rheumatology diseases and target populations. They combine medical, scientific and clinical rheumatology expertise to ensure successful trial management and execution.
A specialized CRO enhances your trial by providing medical, scientific and clinical rheumatology expertise in addition to tailored patient engagement strategies, and streamlined operations. Their deep understanding of regulatory requirements and established rheumatology-specific networks can lead to more efficient trial execution and improved patient outcomes, ultimately advancing treatment options in this critical field.
Wherever
You’re Going,
We’re all in.
Need help with your next study? We want to learn more. Fill out the form on the right and one of our experts will be in touch.
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