Discover 8 Types of Adaptive Designs in Clinical Trials

Adaptive design is paving the way for more efficient and flexible studies. We are thrilled to present 8 types of adaptive designs that are shaping this transformation.  

1. Group sequential
   Allows for one of more pre-planned interim analyses and incorporates predetermined criteria for adaptations.

2. Adaptation to the sample size
   Allows pre-planned adjustments to the sample size based on results from interim analyses.

3. Adaptation to the patient population
   Allows for adjustments to the patient population based on results from interim analyses. For instance, following results from interim analyses, enrolment could be restricted to a specific subpopulation.
   
   
4. Adaptations to treatment arm selection
   Allows for pre-planned modifications of treatment arms based on results from interim analyses (adding or terminating arms).
   
   
5. Seamless phase 2/3
   Design that integrates both Phase 2 and Phase 3 components within the same trial. The transition from Phase 2 and Phase 3 is conducted without interruption.
   
   
6. Adaptations to patient allocation
   Allows for adjustments to allocation of subjects to treatment group based on accumulating data during the trial.
   
   
7. Adaptation to endpoint selection
   Allows for adjustments to the selection of the primary endpoint based on results from interim analyses.
   
   
8. Adaptation to multiple design features
   Combines several adaptive designs.

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For a comprehensive understanding, we recommend reading the full article available:  Potvin D, D'Angelo P, Bennett S, Jankicevic J, Bissonnette R. Adaptive designs in dermatology clinical trials: Current status and future perspectives. J Eur Acad Dermatol Venereol. 2024 Apr 15. doi: 10.1111/jdv.20030. Epub ahead of print. PMID: 38619384.

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